Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	E2f1tm1Meg
Name:	E2F transcription factor 1; targeted mutation 1, Michael E Greenburg
MGI ID:	MGI:1857424
Synonyms:	E2f1-, E2F-1-
Gene:	E2f1  Location: Chr2:154401327-154411812 bp, - strand  Genetic Position: Chr2, 76.79 cM
Alliance:	E2f1tm1Meg page

Germline Transmission:	Earliest citation of germline transmission: J:33100
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 3, intron 3 and exon 4 were replaced with a neomycin cassette. These sequences encode residues encoding the leucine zipper and those critical for DNA binding. Northern blot analysis did not detect a transcript made from this allele in fibroblasts isolated from homozygous embryos. (J:33100)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	78 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying E2f1tm1Meg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:	25 strains or lines available

Original:	J:33100 Field SJ, et al., E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17;85(4):549-61
All:	98 reference(s)