Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crhtm1Maj
Name:	corticotropin releasing hormone; targeted mutation 1, Joseph Majzoub
MGI ID:	MGI:1857392
Synonyms:	CRH -, CRHKO, CRH KO, CRH-KO
Gene:	Crh  Location: Chr3:19747565-19749560 bp, - strand  Genetic Position: Chr3, 5.75 cM
Alliance:	Crhtm1Maj page

Germline Transmission:	Earliest citation of germline transmission: J:23082
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The sequences encoding the pre-propeptide region were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that the transcript was absent in whole brain RNA derived from homozygous mice. Immunohistochemical analysis demonstrated that the protein was not detectable in sections of the amygdala and cerebral cortex of brains of homozygous mice. (J:17994, J:23082, J:47705)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crh Mutation:	42 strains or lines available

Original:	J:23082 Muglia L, et al., Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995 Feb 2;373(6513):427-32
All:	45 reference(s)