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Ttrtm1Wsb
Targeted Allele Detail
Summary
Symbol: Ttrtm1Wsb
Name: transthyretin; targeted mutation 1, William S Blaner
MGI ID: MGI:1857264
Synonyms: ttr-, TTR KO
Gene: Ttr  Location: Chr18:20798337-20807378 bp, + strand  Genetic Position: Chr18, 11.47 cM
Alliance: Ttrtm1Wsb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:4183
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into the second exon disrupted the gene. Western blot analysis of peripheral blood using a rat polyclonal antiserum did not detect protein in homozygous mutant mice. (J:4183)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttr Mutation:  44 strains or lines available
References
Original:  J:4183 Episkopou V, et al., Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2375-9
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory