Ptgs1tm1Unc
Targeted Allele Detail
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Symbol: |
Ptgs1tm1Unc |
Name: |
prostaglandin-endoperoxide synthase 1; targeted mutation 1, University of North Carolina |
MGI ID: |
MGI:1857238 |
Synonyms: |
COX-1-, PGHS-1-, Ptgs1-, Ptgstm1Smi |
Gene: |
Ptgs1 Location: Chr2:36120438-36142284 bp, + strand Genetic Position: Chr2, 24.19 cM
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Alliance: |
Ptgs1tm1Unc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:29511
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A ~1 kb genomic fragment containing intron 10, and the first 44 bp of exon 11 was replaced with a neomycin selection cassette. Northern blot analysis on colon and kidney RNA demonstrated that a 1.1 kb aberrant transcript was produced from this allele. Western blot analysis on kidney, stomach or colon tissue lysates derived from homozygous mice confirmed that no detectable protein is produced from this allele, and additional western blots on proteins derived from LPS-induced macrophages derived from homozygous mice demonstrated that no encoded protein was present.
(J:29511)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptgs1 Mutation: |
44 strains or lines available
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Original: |
J:29511 Langenbach R, et al., Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 1995 Nov 3;83(3):483-92 |
All: |
116 reference(s) |
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