Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Notch1tm1Con
Name:	notch 1; targeted mutation 1, Ronald L Conlon
MGI ID:	MGI:1857230
Synonyms:	N1delta1, Notch-, Notch1-, Notch1tm1Con/J, Notchdelta1
Gene:	Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM
Alliance:	Notch1tm1Con page

Germline Transmission:	Earliest citation of germline transmission: J:25248
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of sequences encoding the EGF repeats 28 to 36, three Notch repeats, the transmembrane domain and CDC10/SWI6 repeats, and replacement with a neomycin gene. (J:25248)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	111 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:	115 strains or lines available

Original:	J:25248 Conlon RA, et al., Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
All:	43 reference(s)