Alox5ap<tm1Jdm> Targeted Allele Detail MGI Mouse (MGI:1857167)

Alox5ap^tm1Jdm
Targeted Allele Detail

Summary

Symbol:	Alox5ap^tm1Jdm
Name:	arachidonate 5-lipoxygenase activating protein; targeted mutation 1, John D McNeish
MGI ID:	MGI:1857167
Synonyms:	FLAP, FLAP -
Gene:	Alox5ap Location: Chr5:149201814-149224963 bp, + strand Genetic Position: Chr5, 89.18 cM, cytoband G3
Alliance:	Alox5ap^tm1Jdm page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:29897
Parent Cell Line:	DBA-252 (ES Cell)
Strain of Origin:	DBA/1LacJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		A PGK-neomycin selection cassette was inserted into coding sequences of the gene. (J:29897)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Alox5ap Mutation:	15 strains or lines available

Notes

Development of a DBA/1LacJ ES cell line enables gene targeting directly on the arthritis-susceptible background, as 129 ES cell lines generate mice that are not susceptible to collagen-induced arthritis (J:29897).

References

Original:	J:29897 Roach ML, et al., A new embryonic stem cell line from DBA/1lacJ mice allows genetic modification in a murine model of human inflammation. Exp Cell Res. 1995 Dec;221(2):520-5
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23