Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Klf1tm1Sho
Name:	Kruppel-like transcription factor 1 (erythroid); targeted mutation 1, Stuart Orkin
MGI ID:	MGI:1857162
Synonyms:	EKLF-
Gene:	Klf1  Location: Chr8:85628611-85631920 bp, + strand  Genetic Position: Chr8, 41.3 cM
Alliance:	Klf1tm1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:25651
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a portion of intron 2 and exon 2, which encodes the zinc-finger DNA-binding domain of the protein. No stable RNA for the targeted gene was detected by RNase protection using RNA from homozygous mutant embryos. (J:25651)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

52048 assay results 3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Klf1 Mutation:	21 strains or lines available

Original:	J:25651 Perkins AC, et al., Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25;375(6529):318-22
All:	20 reference(s)