Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ednrbtm1Ywa Name: endothelin receptor type B; targeted mutation 1, Masashi Yanagisawa MGI ID: MGI:1857161 Synonyms: enrb/enrb Gene: Ednrb  Location: Chr14:104052061-104081838 bp, - strand  Genetic Position: Chr14, 53.05 cM Alliance: Ednrbtm1Ywa page

Colon crypt proliferation in Ednrbtm1Ywa/Ednrbtm1Ywa mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:22206
Parent Cell Line:	JH1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 4.2kb segment of the gene, which contained exon 3. Exon 3 encodes the fourth transmembrane helix of the protein. Functional analysis showed that the allele is null. (J:22206)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:	103 strains or lines available

Original:	J:22206 Hosoda K, et al., Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 1994 Dec 30;79(7):1267-76
All:	25 reference(s)