Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd247tm1Lov
Name:	CD247 antigen; targeted mutation 1, Paul E Love
MGI ID:	MGI:1857142
Synonyms:	CD3zeta-KO, zeta -, zeta/eta-, zeta-KO
Gene:	Cd247  Location: Chr1:165616250-165704846 bp, + strand  Genetic Position: Chr1, 73.14 cM, cytoband G-H
Alliance:	Cd247tm1Lov page

Germline Transmission:	Earliest citation of germline transmission: J:14170
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of a genomic fragment containing exon 2 and an insertion of a neomycin gene into exon 4. Northern blot analysis demonstrated that small amounts of a mutant transcript could be detected in thymocyte and lymph node RNA derived from homozygous mice. Metabolic labeling and immunoprecipitation studies also confirmed that the protein was not detectable in thymocytes from homozygous mice. (J:72520)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd247 Mutation:	11 strains or lines available

Original:	J:14170 Love PE, et al., T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science. 1993 Aug 13;261(5123):918-21
All:	29 reference(s)