Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Agttm1Unc
Name:	angiotensinogen; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857121
Synonyms:	AGT-
Gene:	Agt  Location: Chr8:125283326-125296445 bp, - strand  Genetic Position: Chr8, 72.81 cM
Alliance:	Agttm1Unc page

Germline Transmission:	Earliest citation of germline transmission: J:24156
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment within exon 2 that codes for 114 amino acids of the encoded protein was replaced with a neomycin selection cassette. Radioimmunoassay tests confirmed that no protein was detectable in plasma of homozygous mice. (J:24156)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Agt Mutation:	33 strains or lines available

Original:	J:24156 Kim HS, et al., Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2735-9
All:	21 reference(s)