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Myo15sh2
Radiation induced Allele Detail
Nomenclature
Symbol: Myo15sh2
Name: myosin XV; shaker 2
MGI ID: MGI:1857036
Synonyms: sh2
Gene: Myo15  Location: Chr11:60469339-60528369 bp, + strand  Genetic Position: Chr11, 37.81 cM
Mutation
origin
Strain of Origin:  Mixed stock
Mutation
description
Allele Type:    Radiation induced
Mutation:    Single point mutation
 
Mutation detailsThe sequences of all 49 exons of this gene were analyzed. A G to A transition was found in codon 674 within exon 18 that produces a Cys to Tyr substitution that likely removes an actin binding site. (J:48001)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myo15 Mutation:  87 strains or lines available
Notes
The Myo15sh2 mutation was discovered by Dobrovolskaia-Zavadskaia (J:15021) in descendants of an irradiated male.
References
Original:  J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory