Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Dnah11iv
Name:	dynein, axonemal, heavy chain 11; situs inversus viscerum
MGI ID:	MGI:1856917
Synonyms:	iv
Gene:	Dnah11  Location: Chr12:117841717-118162778 bp, - strand  Genetic Position: Chr12, 63.25 cM
Alliance:	Dnah11iv page

Strain of Origin:

(C3HeB/Fe x STOCK Frem2my)F3

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A G-to-A transition mutation led to a substitution of glutamate with lysine at position 2271 (p.E2271K)in the encoded protein. This residue is located between the second and third P-loop motifs, a highly conserved region that constitutes the motor domain. (J:44093) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	101 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Dnah11 Mutation:	217 strains or lines available

Original:	J:24771 Hummel KP, et al., Situs Viscerum Inversus. Mouse News Lett. 1956;14:21
All:	45 reference(s)