Phenotypes Associated with This Genotype

Genotype
MGI:7551064

• Allelic Composition: Ccdc93^em1(IMPC)J/Ccdc93^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ccdc93^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ccdc93

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ccdc93^em1(IMPC)J/Ccdc93^em1(IMPC)J mice exhibit embryonic lethality between E7.5 and E9.5, growth retardation, poorly organized extraembryonic tissues, failure of primitive streak formation and gastrulation, and increased cell death.

cellular

increased embryonic tissue cell apoptosis ( J:279207 )

• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5

embryo

increased embryonic tissue cell apoptosis ( J:279207 )

• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5

failure to gastrulate ( J:279207 )

• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a small egg cylinder is observed at E7.5

failure of primitive streak formation ( J:279207 )

• no Brachyury (T)-positive cells are present at E7.5

disorganized extraembryonic tissue ( J:279207 )

• extraembryonic tissues are poorly organized at E7.5

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5