Phenotypes for Mesp1 Sp8 MGI:7437667 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sp8^tm1Smb/Sp8^tm2Smb Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (19 available)
Sp8^tm1Smb mutation (0 available); any Sp8 mutation (30 available)
Sp8^tm2Smb mutation (1 available); any Sp8 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:200761 )

N	• 9 of 10 mice exhibited no detectable craniofacial defects

abnormal face development ( J:200761 )

• 1 of 10 mice showed truncation of anterior facial structures

midline facial cleft ( J:200761 )

• 1 of 10 mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a partial facial midline cleft

growth/size/body

abnormal face development ( J:200761 )

• 1 of 10 mice showed truncation of anterior facial structures

midline facial cleft ( J:200761 )

• 1 of 10 mice showed incomplete medial nasal prominence approximation along the facial midline, resulting in a partial facial midline cleft

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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