Phenotypes for Lmna Nat10 MGI:7311572 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lmna^tm1.1Otin/Lmna^tm1.1Otin Nat10^{tm1a(KOMP)Wtsi}/Nat10⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm1.1Otin mutation (0 available); any Lmna mutation (82 available)
Nat10^{tm1a(KOMP)Wtsi} mutation (2 available); any Nat10 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:261974 )

• delayed compared to mice homozygous for the Lmna^tm1.1Otin and wild-type Nat10

reproductive system

reproductive system phenotype ( J:261974 )

N	• unlike mice homozygous for the Lmna^tm1.1Otin, mice do not exhibit penis prolapse

reduced fertility ( J:261974 )

• partially rescued compared to mice homozygous for the Lmna^tm1.1Otin and wild-type Nat10

skeleton

kyphosis ( J:261974 )

• delayed compared to mice homozygous for the Lmna^tm1.1Otin and wild-type Nat10

vision/eye

vision/eye phenotype ( J:261974 )

N	• unlike mice homozygous for the Lmna^tm1.1Otin, mice do not exhibit keratoconjunctivitis sicca

cardiovascular system

decreased heart rate ( J:261974 )

• delayed onset

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
progeria		DOID:3911	OMIM:176670	J:261974

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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