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Phenotypes Associated with This Genotype
Genotype
MGI:7311570
Allelic
Composition
Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1.1Otin mutation (0 available); any Lmna mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
• due to reduced reproductive fitness
• however, normal oocyte production and fertilization with wild-type sperm

adipose tissue
• treatment with Remodelin partially rescues phenotype

cardiovascular system
• increased thickness that is partially rescued by Remodelin treatment

growth/size/body

immune system

renal/urinary system

skeleton

vision/eye

cellular

integument
• treatment with Remodelin partially rescues phenotype

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
J:261974


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/13/2022
MGI 6.21
The Jackson Laboratory