Phenotypes for Rag1 Tnfsf14 MGI:7277703 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rag1^tm1Mom/Rag1^tm1Mom Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (132 available)
Tnfsf14^tm1Kpf mutation (2 available); any Tnfsf14 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased osteoclast cell number ( J:294030 )

increased osteoblast cell number ( J:294030 )

• slight increase

abnormal trabecular bone morphology ( J:294030 )

• increase in cancellous bone structure in comparison to mice null for Rag alone

hematopoietic system

decreased osteoclast cell number ( J:294030 )

immune system

decreased osteoclast cell number ( J:294030 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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