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Phenotypes Associated with This Genotype
Genotype
MGI:7265160
Allelic
Composition
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-IGF1R)1Ramo/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-IGF1R)1Ramo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice administered doxycyline beginning at 21 days of age develop tumors on the lung surface as early as 90 days after doxycycline treatment
• most mice treated with doxycycline for up to 9 months exhibit visible lung tumors (2-30 tumors); tumors show multifocal adenomatous alveolar hyperplasia with papillary and solid adenomas
• mice in which doxycycline is removed after an 8-month treatment period show incomplete tumor regression
• however, bronchiolar hyperplasia is not seen in doxycycline treated mice
• solid adenomas are seen in doxycycline-treated mice

respiratory system
• mice administered doxycyline beginning at 21 days of age develop tumors on the lung surface as early as 90 days after doxycycline treatment
• most mice treated with doxycycline for up to 9 months exhibit visible lung tumors (2-30 tumors); tumors show multifocal adenomatous alveolar hyperplasia with papillary and solid adenomas
• mice in which doxycycline is removed after an 8-month treatment period show incomplete tumor regression
• however, bronchiolar hyperplasia is not seen in doxycycline treated mice
• solid adenomas are seen in doxycycline-treated mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
J:271820


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory