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Phenotypes Associated with This Genotype
Genotype
MGI:7260355
Allelic
Composition
Lmnatm1.1Vde/Lmnatm1.1Vde
Genetic
Background
B6.129(Cg)-Lmnatm1.1Vde
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1.1Vde mutation (0 available); any Lmna mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• during the training stage of the treadmill test, mutant mice exhibit a stable performance at 6 and 12 months of age compared to controls which show decreased performance at 6 months
• during the fatigability stage of the treadmill test, mutant mice spend less time on the electrified grid than wild-type mice at 6 months of age

muscle
• 1-month-old mice show an increase in muscle tone
• however, no differences in grip test are seen in 1-18 month old mice and no muscle abnormalities are seen

behavior/neurological
N
• behavior/neurological phenotype MP:0005386 mice do not show a difference on the rotarod and tail flick experiments show normal pain sensation

nervous system
N
• sciatic nerves in 18-month-old mice appear normal, nerve conduction velocities and action potential amplitudes in sciatic nerves are normal, and no signs of peripheral neuropathy are seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT Charcot-Marie-Tooth disease type 2B1 DOID:0110156 OMIM:605588
J:322912


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory