Analysis Tools
behavior/neurological
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• when feeding or drinking in a novel environment, mice are much slower to feed and to begin drinking and total feeding time or total drinking time in a novel environment is reduced than in wild-type mice, indicating novelty-suppressed feeding and drinking
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• mice do not learn the location of the hidden platform in the Morris water task as readily as wild-type mice
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• in the probe test of the Morris water maze, mice do not show strong preferences for the original platform quadrant used in training and spend less time in the target quadrant and the target-site crossings is much lower
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polyphagia
(
J:281839
)
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• hyperphagia in home cage
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• mice exhibit depression-like behaviors
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• mice show longer periods of immobility in the tail-suspension test and forced swim test than wild-type mice
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• mice exhibit a lower coat score than wild-type mice, suggesting decreased grooming
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hypoactivity
(
J:281839
)
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• mice show altered nonrapid eye movement (NREM) sleep patterns and the NREM sleep wave is less synchronized
• EEG power analysis of NREM sleep wave shows that the peak power (power at peak frequency) and the total delta power (.5-4 Hz) of NREM sleep wave is reduced
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• mice spend more time in rapid eye movement (REM) sleep; throughout the circadian cycle, mice spend approximately twice as much time in REM sleep than wild-type mice
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• mice exhibit defects in nesting behavior, with poorly constructed nests in home cages
• nest-building behavior when placed in a novel environment is more impaired in than in wild-type mice
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• mice spend much less time interacting with a target mouse in the three-chamber sociability test
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nervous system
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• cornu ammonis (CA)1 is smaller
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• cultured cortical neurons exhibit reduced dendritic arborization
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• the resting membrane potentials of CA1 pyramidal neurons are more hyperpolarized
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• synaptic activity at the CA3-CA1 Schaffer-collateral synapse and CA1 neuronal activity are drastically reduced
• the amplitude of population spikes in the CA1 pyramidal layer is smaller
• upon electrical shock stimulation, CA1 neurons show only weak responses instead of pronounced calcium spikes as in wild-type mice, indicating that CA1 neurons are less active
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• the field excitatory postsynaptic potential at the CA3-CA1 synapse is lower, while the amplitude of presynaptic volley is normal
• in whole-cell recording of CA1 pyramidal neurons, both the amplitude and frequency of spontaneous excitatory postsynaptic potentials are strongly reduced in neurons
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• four-train long-term potentiation (LTP), induced with four trains of high-frequency stimulation, is lower, but it does persist for at least 150 minutes, indicating depressed long-lasting long-term potentiation at the Schaffer-collateral synapses
• however, mice exhibit one-train LTP, induced with one train of high-frequency stimulation, that is comparable with wild-type mice
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taste/olfaction
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| major depressive disorder | DOID:1470 |
OMIM:608520 OMIM:608691 |
J:281839 | |
