Phenotypes Associated with This Genotype

Genotype
MGI:6825757

• Allelic Composition: Abcc9^em3Nich/Abcc9⁺
• Genetic Background: B6.Cg-Abcc9^em3Nich

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:308986 )

N • slope compliance (reflecting noncontractile biomechanical properties) and blood pressure are not different from controls

dilated aorta ( J:308986 )

• aortic diameter is greater at all pressures

abnormal myocardial fiber morphology ( J:308986 )

• ATP-sensitive potassium [K(ATP)] channel density is much lower in myocytes

enlarged heart ( J:308986 )

• hearts are larger

dilated heart ( J:308986 )

• chamber dilation

abnormal myocardial fiber currents ( J:308986 )

• K(ATP) current is reduced in ventricular myocytes

• however, no elevation of basal K(ATP) conductance in isolated aortic smooth muscle cells is seen

growth/size/body

enlarged heart ( J:308986 )

• hearts are larger

muscle

abnormal myocardial fiber morphology ( J:308986 )

• ATP-sensitive potassium [K(ATP)] channel density is much lower in myocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrichotic osteochondrodysplasia Cantu type		DOID:0060569	OMIM:239850	J:308986