Phenotypes Associated with This Genotype

Genotype
MGI:6726370

• Allelic Composition: Abcg2^em1Omw/Abcg2^em1Omw
• Genetic Background: C57BL/6J-Abcg2^em1Omw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestine physiology ( J:292268 )

♂ • intestinal loop assays looking at urate flux, show a near complete loss of intestinal excretion of urate

homeostasis/metabolism

increased blood uric acid level ( J:292268 )

♂ • males, but not females, exhibit an increase in serum urate

increased circulating glucose level ( J:292268 )

♂ • increase in serum glucose in males but not females

increased circulating insulin level ( J:292268 )

♂ • increase in serum insulin levels in males but not females

increased circulating insulin-like growth factor I level ( J:292268 )

♂ • increase in serum insulin-like growth factor 1 in males but not females

increased circulating potassium level ( J:292268 )

♂ • in males but not females

increased urine sodium level ( J:292268 )

♂ • males show an increase in the fractional excretion of sodium

increased urine osmolality ( J:292268 )

♂ • in males but not females

liver/biliary system

hepatic steatosis ( J:292268 )

♂ • males exhibit sporadic fatty liver

renal/urinary system

increased urine sodium level ( J:292268 )

♂ • males show an increase in the fractional excretion of sodium

increased urine osmolality ( J:292268 )

♂ • in males but not females

abnormal kidney physiology ( J:292268 )

♂ • fractional excretion of urate is decreased in males

♂ • however, the reduced fractional excretion of urate coupled with an increased urate load results in no increase in urinary urate excretion

decreased renal glomerular filtration rate ( J:292268 )

♂ • males exhibit a decrease in glomerular filtration rate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperuricemia		DOID:1920		J:292268