About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6515750
Allelic
Composition
Vcpip1em1Zlou/Vcpip1em1Zlou
Genetic
Background
C57BL/6NHsd-Vcpip1em1Zlou
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcpip1em1Zlou mutation (0 available); any Vcpip1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• significant senescence of inguinal adipose tissue (IAT)

cellular
• large increase in number of abnormal chromosomes in mouse embryo fibroblasts (MEFs)
• significant increase in number of micronuclei in normochromic erythrocytes (NCEs)
• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs
• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)
• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs
• hypersensitive to DNA-protein crosslink (DPC)-inducing agents formaldehyde (FA), camptothecin (CPT) and cisplatin in mouse embryo fibroblasts (MEFs)
• large increase in number of abnormal chromosomes in mouse embryo fibroblasts (MEFs)
• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)
• significant increase in number of micronuclei in normochromic erythrocytes (NCEs)
• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs

growth/size/body

homeostasis/metabolism
• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)
• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in liver at age 4 months and in MEFs

mortality/aging
• reduced median lifespan

skeleton
• at age 10 months
• at age 10 months

vision/eye
• increased incidence of cataracts at age 10 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
J:297179


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/22/2022
MGI 6.21
The Jackson Laboratory