About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6505557
Allelic
Composition		 Apctm2Rak/Apc+
Krastm1.1Khai/Kras+
Tg(Fabp1-cre)1Jig/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2Rak mutation (1 available); any Apc mutation (154 available)
Krastm1.1Khai mutation (1 available); any Kras mutation (76 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon adenoma incidence ( J:276349 )
• mice develop colonic tumors, characterized as adenomas with low-grade dysplasia

mortality/aging
premature death ( J:276349 )
• mice show slightly longer survival than conditional mice carrying the Krastm4Tyj allele

digestive/alimentary system
increased colon adenoma incidence ( J:276349 )
• mice develop colonic tumors, characterized as adenomas with low-grade dysplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
 J:276349

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory