About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6500742
Allelic
Composition
Ace2em1Cgen/Y
Genetic
Background
C57BL/6-Ace2em1Cgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2em1Cgen mutation (0 available); any Ace2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice with DSS-induced inflammatory bowel disease show increased infiltration of inflammatory cells
• mice exhibit increased susceptibility to inflammatory bowel disease (IBD), with mice showing more pronounced weight loss, earlier bloody feces and higher feces album level, increased destruction of intestinal architecture and crypts loss, increased infiltration of inflammatory cells, obvious edema and reduction in colon length after dextran sodium sulfate (DSS) administration

digestive/alimentary system
• mice show increased destruction of intestinal architecture and crypt loss when treated with DSS to induce IBD
• mice with DSS-induced IBD show a reduction in colon length
• mice with DSS-induced IBD show obvious edema
• mice show higher feces album level when treated with DSS to induce IBD
• mice with DSS-induced IBD show earlier blood feces than in wild-type mice
• ATP-induced intracellular calcium concentration is higher in intestinal organoids, indicating a calcium overload
• permeability of intestinal organoids is increased
• mice show a slower regeneration of intestinal organoids than in wild-type mice, showing a smaller size and slowed differentiation
• mice with DSS-induced inflammatory bowel disease show increased infiltration of inflammatory cells
• mice exhibit increased susceptibility to inflammatory bowel disease (IBD), with mice showing more pronounced weight loss, earlier bloody feces and higher feces album level, increased destruction of intestinal architecture and crypts loss, increased infiltration of inflammatory cells, obvious edema and reduction in colon length after dextran sodium sulfate (DSS) administration

growth/size/body
• mice show increased weight loss when treated with dextran sodium sulfate to induce IBD

homeostasis/metabolism
• mice with DSS-induced IBD show obvious edema

cellular
• reactive oxygen species (ROS) production is elevated in intestinal organoids


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/07/2021
MGI 6.17
The Jackson Laboratory