Phenotypes Associated with This Genotype

Genotype
MGI:6472965

• Allelic Composition: Grhpr^{Gt(OST383093)Lex}/Grhpr^{Gt(OST383093)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperoxaluria ( J:283585 )

• both males and females exhibit an increase in urinary oxalate excretion, with males excreting more urinary oxalate than females

• however, mice do not show changes in urinary glycolate levels

increased physiological sensitivity to xenobiotic ( J:283585 )

♂ • males fed a 1% hydroxyproline diet exhibit renal oxalosis

renal/urinary system

hyperoxaluria ( J:283585 )

• both males and females exhibit an increase in urinary oxalate excretion, with males excreting more urinary oxalate than females

• however, mice do not show changes in urinary glycolate levels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperoxaluria type 2		DOID:0111671	OMIM:260000	J:283585