Phenotypes Associated with This Genotype

Genotype
MGI:6467541

• Allelic Composition: Tg(SERPINA1-TAg)1812Jtsb/0
• Genetic Background: involves: C3H * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:101633 )

• mean survival time is 12.8 weeks due to liver tumors

neoplasm

increased hepatocellular carcinoma incidence ( J:101633 )

• mice develop liver tumors by 10 weeks of age; development of tumors occurs in 4 stages, with no liver changes in embryonic/fetal stages, hyperplastic liver with crowding of hepatocyte nuclei due to reduced cytoplasm in newborns to 2 week old mice, diffuse liver cell dysplasia without tumor nodules between 3 and 8 weeks of age, and hepatocellular carcinoma after 8 weeks of age

• hepatocellular carcinomas are usually of well-differentiated cell type similar to human hepatomas with trabecular, solid, acinar, or tubular patterns

liver/biliary system

bile duct hyperplasia ( J:101633 )

• hyperplastic bile ducts are occasionally seen in nontumoral areas of the liver

increased hepatocellular carcinoma incidence ( J:101633 )

• mice develop liver tumors by 10 weeks of age; development of tumors occurs in 4 stages, with no liver changes in embryonic/fetal stages, hyperplastic liver with crowding of hepatocyte nuclei due to reduced cytoplasm in newborns to 2 week old mice, diffuse liver cell dysplasia without tumor nodules between 3 and 8 weeks of age, and hepatocellular carcinoma after 8 weeks of age

• hepatocellular carcinomas are usually of well-differentiated cell type similar to human hepatomas with trabecular, solid, acinar, or tubular patterns

endocrine/exocrine glands

bile duct hyperplasia ( J:101633 )

• hyperplastic bile ducts are occasionally seen in nontumoral areas of the liver

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:101633