Analysis Tools
behavior/neurological
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• in a delayed nonmatching to place paradigm task placing varying demands on spatial discrimination ability, mice show alternations in spatial pattern separation function and a higher sensitivity to high proactive interferences
• however, mice show normal spatial working memory
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• in a massed training protocol performed within a single day in the water maze, mice learn the task similarly to wild-type mice but when spatial long-term memory is probed 10 days later, mice spend as much time in the target quadrant as in other quadrants, exhibit a smaller number of crossings of the platform location, and show slightly longer distance swum before reaching the target platform position indicating normal spatial learning but long-term spatial memory deficits in the more difficult massed training protocol
• however, mice show normal locomotion and exploration, no alternation of anxiety-like behaviors, and do not show spatial learning and memory deficits in a distributed protocol in the water maze
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nervous system
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• young immature newborn neurons undergo accelerated death during the critical period of 18-28 days after birth which is associated with deficient functional maturation of young newborn dentate granule cells
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• total length of dendrites of immature DCX+ neurons is shorter, with less dendritic branching
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• post-recall activation of mature dentate granule cells is unaffected, but mice show a complete failure of activation of young DCX+ newborn neurons in response to memory recall suggesting they are not recruited during the memory task
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cellular
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• young immature newborn neurons undergo accelerated death during the critical period of 18-28 days after birth which is associated with deficient functional maturation of young newborn dentate granule cells
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| non-syndromic X-linked intellectual disability 30 | DOID:0112051 |
OMIM:300558 |
J:292116 | |
