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Phenotypes Associated with This Genotype
Genotype
MGI:6448362
Allelic
Composition		 Ddb1tm1Spg/Ddb1tm1Spg
Plekha5Tg(AMH-cre)1Flor/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb1tm1Spg mutation (0 available); any Ddb1 mutation (34 available)
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:291677 )
• reduced sperm count in epididymis at age 10 weeks
abnormal seminiferous tubule morphology ( J:291677 )
• reduced number at birth and age P2
• some vacuolated tubules at age 10 weeks
decreased Sertoli cell number ( J:291677 )
• normal in E18 embryos
• at birth
ectopic Sertoli cells ( J:291677 )
• some cells found in tubule lumen at birth
• normal in E18 embryos
enlarged seminiferous tubules ( J:291677 )
• at birth and age P2
• normal size at age P14 and in adult mice
abnormal testis cord formation ( J:291677 )
• enlarged at birth and age P2
• normal in E14 and E18 embryos
small testis ( J:291677 )
• at age P14, P35 and 10 weeks

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:291677 )
• reduced number at birth and age P2
• some vacuolated tubules at age 10 weeks
decreased Sertoli cell number ( J:291677 )
• normal in E18 embryos
• at birth
ectopic Sertoli cells ( J:291677 )
• some cells found in tubule lumen at birth
• normal in E18 embryos
enlarged seminiferous tubules ( J:291677 )
• at birth and age P2
• normal size at age P14 and in adult mice
abnormal testis cord formation ( J:291677 )
• enlarged at birth and age P2
• normal in E14 and E18 embryos
small testis ( J:291677 )
• at age P14, P35 and 10 weeks

cellular
oligozoospermia ( J:291677 )
• reduced sperm count in epididymis at age 10 weeks

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory