Phenotypes Associated with This Genotype

Genotype
MGI:6441186

• Allelic Composition: Card14^em2Tshu/Card14⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:289239 )

• normal numbers of pups are seen at 1-3 days after birth but fewer than the expected numbers of mice are seen at 3 weeks of age, indicating lower survival rate

integument

skin inflammation ( J:289239 )

• mice exhibit redness and swelling of ears and roughness of tails

• however, the systemic immune response is not affected, with mice showing normal spleen, thymus, and lymph node sizes and normal percentages of B220+ B cells, CD4+ and CD8+ T cells, CD11b+Ly6G+ neutrophils, CD11b+F4/80+ macrophages, and CD11c+MHCII+ dendritic cells

acanthosis ( J:289239 )

• epidermal acanthosis is seen in the ear, tail and back at 20 days of age

thick epidermis ( J:289239 )

• epidermal thickening of the ears and tail

• mice treated with an IL-17A-blocking antibody show partial reduction of ear thickness

psoriasis ( J:289239 )

• mice develop a psoriasis-like phenotype

• mice treated with the NF-KappaB inhibitor BAY11-7082 show attenuation of the skin phenotype

immune system

increased alpha-beta T cell number ( J:289239 )

• the percentage and total number of infiltrated IL-17A+ T cells is increased in the ears; most IL-17A+ lymphocytes in the ears are alpha-beta T cells

abnormal gamma-delta T cell number ( J:289239 )

• mice show increased proportion and absolute numbers of gamma-delta TCR^neg T cells but decreased percentage of gamma-delta TCR^mid and gamma-delta TCR^hi T cells

skin inflammation ( J:289239 )

• mice exhibit redness and swelling of ears and roughness of tails

• however, the systemic immune response is not affected, with mice showing normal spleen, thymus, and lymph node sizes and normal percentages of B220+ B cells, CD4+ and CD8+ T cells, CD11b+Ly6G+ neutrophils, CD11b+F4/80+ macrophages, and CD11c+MHCII+ dendritic cells

hematopoietic system

increased alpha-beta T cell number ( J:289239 )

• the percentage and total number of infiltrated IL-17A+ T cells is increased in the ears; most IL-17A+ lymphocytes in the ears are alpha-beta T cells

abnormal gamma-delta T cell number ( J:289239 )

• mice show increased proportion and absolute numbers of gamma-delta TCR^neg T cells but decreased percentage of gamma-delta TCR^mid and gamma-delta TCR^hi T cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis 2		DOID:0080475	OMIM:602723	J:289239