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Phenotypes Associated with This Genotype
Genotype
MGI:6438116
Allelic
Composition
Shank3tm3.2Cmpl/Shank3tm3.2Cmpl
Genetic
Background
B6.129S6(Cg)-Shank3tm3.2Cmpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm3.2Cmpl mutation (0 available); any Shank3 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal locomotor activity and locomotor habituation, normal ambulatory movement and fine movement, and unchanged motor coordination and learning on the accelerating rotarod
• mice show no differences in anxiety-related behavior in the open field, dark/light, and elevated plus maze tasks, show normal marble burying and nest building and show normal acoustic startle reflex and prepulse inhibition
• mice show no differences in both cued and contextual fear conditioning
• in the novel object recognition test, mice show no preference for novel object B over control object C compared to wild-type mice which show a preference for the new object B
• during a spatial test, mice show no preference for object A in the new location compared to wild-type mice which show a preference for object A
• however, mice show normal long-term spatial memory in the Morris water maze
• mice show an increase in % thigmotaxis across training days in the Morris water maze
• mice spend almost twice as much time grooming in a novel home-cage than wild-type mice; this is due increased time grooming per bout and not due to increased number of grooming bouts
• mice interact less times and spend less time physically interacting with their sex and genotype-matched counterpart in the open field than wild-type mice
• however, mice show normal social recognition in the social interaction with juvenile test of social memory, and normal social interaction with a caged adult
• pups temporarily isolated from their mothers emit more ultrasonic vocalization calls than wild-type mice at P4 and P6

nervous system
• mice exhibit altered hippocampal synaptic plasticity
• NMDA/AMPA ratio is decreased at glutamatergic synapses onto medium spiny neurons indicating that striatal excitatory transmission is impaired
• however, no difference in mEPSC amplitude or frequency is seen in the striatum and mice do not show altered synaptic transmission at hippocampal synapses
• mice show decreased hippocampal long-term potentiation
• however, mGluR-dependent long-term depression is not altered


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory