Phenotypes Associated with This Genotype

Genotype
MGI:6433845

• Allelic Composition: Plat^tm1Mlg/Plat^tm1Mlg
• Genetic Background: B6.129S2-Plat^tm1Mlg/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal susceptibility to Coronaviridae infection ( J:288556 )

• mice infected with a sublethal dose of mouse-adapted SARS-CoV MA15 show a slight, but not significant, acceleration in recovery of weight loss compared to controls

• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover

• SARS-CoV MA15 lethally infected mice show a trend toward less hemorrhage in the lungs

• however, SARS-CoV MA15-infected mice show similar viral loads in the lung at 4 and 7 days post infection as wild-type controls

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:288556 )

• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:288556 )

• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover