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Phenotypes Associated with This Genotype
Genotype
MGI:6433845
Allelic
Composition
Plattm1Mlg/Plattm1Mlg
Genetic
Background
B6.129S2-Plattm1Mlg/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plattm1Mlg mutation (6 available); any Plat mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice infected with a sublethal dose of mouse-adapted SARS-CoV MA15 show a slight, but not significant, acceleration in recovery of weight loss compared to controls
• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover
• SARS-CoV MA15 lethally infected mice show a trend toward less hemorrhage in the lungs
• however, SARS-CoV MA15-infected mice show similar viral loads in the lung at 4 and 7 days post infection as wild-type controls
• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover

mortality/aging
• mice infected with a lethal dose of SARS-CoV MA15 show early mortality compared to wild-type controls, although mice that survive early infection recover


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory