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Phenotypes Associated with This Genotype
Genotype
MGI:6433074
Allelic
Composition
Tlr3tm1Flv/Tlr3tm1Flv
Genetic
Background
B6N.129S1-Tlr3tm1Flv/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3tm1Flv mutation (6 available); any Tlr3 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice infected intranasally with the mouse-adapted rMA15-SARS-CoV show greater weight loss, increased viral titers in the lungs, increased lung function impairment and lung pathology
• viral titers in the lungs of rMA15-SARS-CoV-infected mice are increased 4-fold at 2 days post-infection (dpi), 20-fold at 4 dpi, and still detectable on 7 dpi, a time by which the virus is cleared in wild-type mice

respiratory system
• rMA15-SARS-CoV-infected mice show impaired lung function


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory