Phenotypes Associated with This Genotype

Genotype
MGI:6433074

• Allelic Composition: Tlr3^tm1Flv/Tlr3^tm1Flv
• Genetic Background: B6N.129S1-Tlr3^tm1Flv/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:288471 )

• mice infected intranasally with the mouse-adapted rMA15-SARS-CoV show greater weight loss, increased viral titers in the lungs, increased lung function impairment and lung pathology

• viral titers in the lungs of rMA15-SARS-CoV-infected mice are increased 4-fold at 2 days post-infection (dpi), 20-fold at 4 dpi, and still detectable on 7 dpi, a time by which the virus is cleared in wild-type mice

respiratory system

abnormal respiratory function ( J:288471 )

• rMA15-SARS-CoV-infected mice show impaired lung function