Phenotypes Associated with This Genotype

Genotype
MGI:6431340

• Allelic Composition: Ace2^{em1(ACE2)Yowa}/Ace2^{em1(ACE2)Yowa}
• Genetic Background: C57BL/6-Ace2^{em1(ACE2)Yowa}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal circulating cytokine level ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show elevated cytokine production that includes eotaxin, G-CSF, IFN-gamma, IL-9 and MIP-1beta

increased circulating interferon-gamma level ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show elevated IFN-gamma levels

increased circulating interleukin-9 level ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show elevated IL-9 levels

interstitial pneumonia ( J:288243 )

♀ • young and aged SARS-CoV-2-infected mice develop interstitial pneumonia characterized by inflammatory cell infiltration, alveolar septal thickening, and vascular system injury

♀ • aged SARS-CoV-2-infected mice show more neutrophil and macrophage infiltration

increased susceptibility to Coronaviridae infection ( J:288243 )

♀ • mice show increased susceptibility to intranasal infection with SARS-CoV-2 (strain BetaCoV/wuhan/AMMS01/2020) compared to wild-type mice, with viral RNA replication in lung Clara cells and in trachea and brain

♀ • aged mice infected intranasally with SARS-CoV-2 lose 10% of weight at 3 days post infection (dpi) but recover

♀ • both young and aged mice intranasally infected with SARS-CoV-2 show viral RNA replication in spleen, kidney, liver, intestine, and serum and viral S protein along the airway

♀ • intragastric SARS-CoV-2-infected mice show viral RNA levels in the trachea and lung and interstitial inflammation with alveolar septal thickening without clinical signs

cardiovascular system

lung hemorrhage ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show more focal hemorrhage than infected young mice

homeostasis/metabolism

abnormal circulating cytokine level ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show elevated cytokine production that includes eotaxin, G-CSF, IFN-gamma, IL-9 and MIP-1beta

increased circulating interferon-gamma level ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show elevated IFN-gamma levels

increased circulating interleukin-9 level ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show elevated IL-9 levels

respiratory system

lung hemorrhage ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show more focal hemorrhage than infected young mice

interstitial pneumonia ( J:288243 )

♀ • young and aged SARS-CoV-2-infected mice develop interstitial pneumonia characterized by inflammatory cell infiltration, alveolar septal thickening, and vascular system injury

♀ • aged SARS-CoV-2-infected mice show more neutrophil and macrophage infiltration

abnormal pulmonary alveolus epithelial cell morphology ( J:288243 )

♀ • aged SARS-CoV-2-infected mice show more lesions of alveolar epithelial cells than infected young mice

thick pulmonary interalveolar septum ( J:288243 )

• both young and aged mice intranasally infected with SARS-CoV-2 show alveolar septal thickening; also observed in intagastric SARS-CoV-2-infected mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
COVID-19		DOID:0080600		J:288243