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Phenotypes Associated with This Genotype
Genotype
MGI:6431340
Allelic
Composition
Ace2em1(ACE2)Yowa/Ace2em1(ACE2)Yowa
Genetic
Background
C57BL/6-Ace2em1(ACE2)Yowa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2em1(ACE2)Yowa mutation (0 available); any Ace2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• aged SARS-CoV-2-infected mice show elevated cytokine production that includes eotaxin, G-CSF, IFN-gamma, IL-9 and MIP-1beta
• aged SARS-CoV-2-infected mice show elevated IFN-gamma levels
• aged SARS-CoV-2-infected mice show elevated IL-9 levels
• young and aged SARS-CoV-2-infected mice develop interstitial pneumonia characterized by inflammatory cell infiltration, alveolar septal thickening, and vascular system injury
• aged SARS-CoV-2-infected mice show more neutrophil and macrophage infiltration
• mice show increased susceptibility to intranasal infection with SARS-CoV-2 (strain BetaCoV/wuhan/AMMS01/2020) compared to wild-type mice, with viral RNA replication in lung Clara cells and in trachea and brain
• aged mice infected intranasally with SARS-CoV-2 lose 10% of weight at 3 days post infection (dpi) but recover
• both young and aged mice intranasally infected with SARS-CoV-2 show viral RNA replication in spleen, kidney, liver, intestine, and serum and viral S protein along the airway
• intragastric SARS-CoV-2-infected mice show viral RNA levels in the trachea and lung and interstitial inflammation with alveolar septal thickening without clinical signs

cardiovascular system
• aged SARS-CoV-2-infected mice show more focal hemorrhage than infected young mice

homeostasis/metabolism
• aged SARS-CoV-2-infected mice show elevated cytokine production that includes eotaxin, G-CSF, IFN-gamma, IL-9 and MIP-1beta
• aged SARS-CoV-2-infected mice show elevated IFN-gamma levels
• aged SARS-CoV-2-infected mice show elevated IL-9 levels

respiratory system
• aged SARS-CoV-2-infected mice show more focal hemorrhage than infected young mice
• young and aged SARS-CoV-2-infected mice develop interstitial pneumonia characterized by inflammatory cell infiltration, alveolar septal thickening, and vascular system injury
• aged SARS-CoV-2-infected mice show more neutrophil and macrophage infiltration
• aged SARS-CoV-2-infected mice show more lesions of alveolar epithelial cells than infected young mice
• both young and aged mice intranasally infected with SARS-CoV-2 show alveolar septal thickening; also observed in intagastric SARS-CoV-2-infected mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
COVID-19 DOID:0080600 J:288243


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory