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Phenotypes Associated with This Genotype
Genotype
MGI:6405398
Allelic
Composition
Tardbptm1.1Neas/Tardbptm1.1Neas
Genetic
Background
B6(C3)-Tardbptm1.1Neas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbptm1.1Neas mutation (0 available); any Tardbp mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no motor neuron loss is seen in the L4-5 spinal cord at 1, 1.5 or 2 years of age and no TDP-43 aggregation in ChAT+ neurons is seen in the lumbar spinal cord
• 2 year old mice show microgliosis in the lumbar spinal cord
• 2 year old mice show astrocytosis in the lumbar spinal cord
• denervation of the tibialis anterior muscle is seen at around 2.5 years of age but not 2 years, with asymmetric innervation of the tibialis anterior muscle and mice with the most denervation also showing the highest degree of asymmetry

immune system
• 2 year old mice show microgliosis in the lumbar spinal cord

hematopoietic system
• 2 year old mice show microgliosis in the lumbar spinal cord

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 10 DOID:0060201 OMIM:612069
J:283769


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory