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Phenotypes Associated with This Genotype
Genotype
MGI:6403905
Allelic
Composition
Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)861Mmul/Tg(ANPEP)861Mmul
Genetic
Background
involves: 129S/SvEv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (51 available)
Tg(ANPEP)861Mmul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice inoculated through oral, intranasal, intragastic and intraperitoneal routes with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37) are permissive to infection, showing large amounts of virus in the lungs and the gut, and also in the spleen and liver, with mice surviving at least 18 days after infection, showing a mild loss of weight and slight temperature increase, and hemorrhaging areas in lung and small intestines
• mice administered HCoV-229E-37 through the nasal rout show virus growth in the lung but not in the gut, liver or spleen

cardiovascular system
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the lung, mainly between 2 and 4 days post infection
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the small intestine, mainly between 2 and 4 days post infection

respiratory system
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the lung, mainly between 2 and 4 days post infection

digestive/alimentary system
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the small intestine, mainly between 2 and 4 days post infection

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:99728


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory