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Phenotypes Associated with This Genotype
Genotype
MGI:6403356
Allelic
Composition
EgfrMhdadsk5/Egfr+
Genetic
Background
involves: 129S1/SvImJ * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EgfrMhdadsk5 mutation (0 available); any Egfr mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice infected with a mouse adapted (MA15) version of severe acute respiratory syndrome coronavirus (SARS-CoV) show enhanced lung damage compared to wild-type mice, showing increased perivascular inflammation with interstitial edema, and alveolar and interstitial spaces filled with proteinaceous fluid and inflammatory cells, however they show a similar weight loss, viral titer, and recovery as wild-type control mice
• aged mice (20-24 weeks old) show increased susceptibility to SARS-CoV infection compared to older wild-type mice, showing higher levels of lung damage, increased edema, perivascular cuffing, interstitial inflammation and cuffing around airways, and enhanced cellular proliferation in lungs
• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

mortality/aging
• aged mice infected with SARS-CoV show 80% lethality by 5 dpi compared to 30% lethality in wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:243599


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory