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Phenotypes Associated with This Genotype
Genotype
MGI:6402915
Allelic
Composition		 Ace2tm1Pngr/Ace2tm1Pngr
Genetic
Background		 B6.129P2-Ace2tm1Pngr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation (1 available); any Ace2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Coronaviridae infection ( J:286299 )
• mice show decreased susceptibility to intranasal infection with severe acute respiratory syndrome coronavirus (SARS-CoV; Beijing strain, PUMC01 isolate) , showing lower levels of infectious virus in the lungs, reduced copy numbers of the SARS-CoV Spike RNA, and reduced pathologic alterations in lungs compared to infected wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory