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Phenotypes Associated with This Genotype
Genotype
MGI:6402915
Allelic
Composition
Ace2tm1Pngr/Ace2tm1Pngr
Genetic
Background
B6.129P2-Ace2tm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation (1 available); any Ace2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice show decreased susceptibility to intranasal infection with severe acute respiratory syndrome coronavirus (SARS-CoV; Beijing strain, PUMC01 isolate) , showing lower levels of infectious virus in the lungs, reduced copy numbers of the SARS-CoV Spike RNA, and reduced pathologic alterations in lungs compared to infected wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory