About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6402445
Allelic
Composition
Tg(CAG-DPP4)4Yuzh/0
Genetic
Background
C57BL/6-Tg(CAG-DPP4)4Yuzh
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice infected with the EMC2012 strain of Middle East respiratory coronavirus (MERS-CoV) all die by day 10 post infection

immune system
• spleen of MERS-CoV-infected mice shows necrosis of splenic cells and increased reticulum cells in red pulp with hemosiderin deposition at 5 and 9 dpi
• MERS-CoV-infected mice show an increase in cytokines such as IFN-gamma, IP-10, and IL-17 in the serum on 5 dpi
• serum IFN-gamma levels are increased at 5 dpi with MERS-CoV
• serum IL-17 levels are increased at 5 dpi with MERS-CoV
• MERS-CoV-infected mice show characteristics of viral encephalitis in the brain at 9 dpi, with perivascular cuffs and neuronal cell necrosis in the cerebral cortex
• MERS-CoV-infected mice show mild to moderate liver damage on 5 dpi, including scattered hepatocyte necrosis and numerous activated Kupffer cells and macrophage infiltrates in hepatic sinusoid and by 9 dpi, fatty change in hepatocytes with less necrosis is seen
• MERS-CoV-infected mice show mild interstital inflammation in the kidneys with inflammatory cell infiltration in the interstitium and exudates of renal tubules on 5 dpi and increased renal tubular epithelial cell injury with focal hemorrhage in the renal interstitium by 9 dpi
• MERS-CoV-infected mice show mild inflammation in the lungs with focal exudation and hemorrhage at 5 days post infection (dpi), and more severe damage with diffused alveolar damage, alveolar septal thickening, hemorrhage, and activated macrophage infiltration at 9 dpi
• mice infected with the EMC2012 strain of Middle East respiratory coronavirus (MERS-CoV) exhibit decreased activity and weigh less from day 6 after infection and die by 10 days post infection (dpi)
• type I and type II pneumocytes in the lungs, tubular epithelial cells in the kidneys, and neuronal cell bodies, dendrites, axons, and some microglia in the cerebral cortex, including the hippocampus, express viral antigen
• mice infected with the EMC2012 strain of Middle East respiratory coronavirus (MERS-CoV) all die by day 10 post infection

respiratory system
• lungs show hemorrhage at 5 dpi with MERS-CoV
• MERS-CoV-infected mice show mild inflammation in the lungs with focal exudation and hemorrhage at 5 days post infection (dpi), and more severe damage with diffused alveolar damage, alveolar septal thickening, hemorrhage, and activated macrophage infiltration at 9 dpi

behavior/neurological
• MERS-CoV infected mice show symptoms of neural defects with paralysis on day 9 after infection

cardiovascular system
• lungs show hemorrhage at 5 dpi with MERS-CoV
• focal hemorrhage in the renal interstitium is seen at 9 dpi with MERS-CoV

hematopoietic system
• spleen of MERS-CoV-infected mice shows necrosis of splenic cells and increased reticulum cells in red pulp with hemosiderin deposition at 5 and 9 dpi

homeostasis/metabolism
• MERS-CoV-infected mice show an increase in cytokines such as IFN-gamma, IP-10, and IL-17 in the serum on 5 dpi
• serum IFN-gamma levels are increased at 5 dpi with MERS-CoV
• serum IL-17 levels are increased at 5 dpi with MERS-CoV

liver/biliary system
• MERS-CoV-infected mice show mild to moderate liver damage on 5 dpi, including scattered hepatocyte necrosis and numerous activated Kupffer cells and macrophage infiltrates in hepatic sinusoid and by 9 dpi, fatty change in hepatocytes with less necrosis is seen

nervous system
• MERS-CoV-infected mice show characteristics of viral encephalitis in the brain at 9 dpi, with perivascular cuffs and neuronal cell necrosis in the cerebral cortex

renal/urinary system
• focal hemorrhage in the renal interstitium is seen at 9 dpi with MERS-CoV
• MERS-CoV-infected mice show mild interstital inflammation in the kidneys with inflammatory cell infiltration in the interstitium and exudates of renal tubules on 5 dpi and increased renal tubular epithelial cell injury with focal hemorrhage in the renal interstitium by 9 dpi

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Middle East respiratory syndrome DOID:0080642 J:286175


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/19/2021
MGI 6.16
The Jackson Laboratory