Phenotypes Associated with This Genotype

Genotype
MGI:6400995

• Allelic Composition: Nlgn1^em1Taku/Nlgn1⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:247060 )

N • no differences in olfactory habituation/dishabituation and novel object recognition test are seen and mice show normal vocalization, no differences in repetitive behavior with regards to grooming and marble burying test, no differences in general locomotor activity, anxiety-like behavior in the elevated plus-maze, and acoustic startle response

abnormal spatial reference memory ( J:247060 )

• in the probe trail of the Morris water maze test, mice spend less time in the target quadrant than wild-type mice and mice do not exhibit a difference between time in the target and adjacent quadrants, indicating impaired spatial memory

decreased aggression towards mice ( J:247060 )

• in the tube test for social dominance, heterozygotes more often retreat from wild-type mice

abnormal social investigation ( J:247060 )

• social preference index in the three-chamber test is lower than in wild-type mice

• in the caged social interaction test, mice show reduced interaction time with a stranger mouse, suggesting impaired social interaction

• however, mice show similar social behavior regarding time in chamber and time spent sniffing the stranger mouse versus inanimate object as wild-type mice in the three-chamber social interaction test

nervous system

nervous system phenotype ( J:247060 )

N • hippocampal neurons show normal spine numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:247060