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Phenotypes Associated with This Genotype
Genotype
MGI:6400427
Allelic
Composition
Dpp4em1Rba/Dpp4+
Genetic
Background
C57BL/6J-Dpp4em1Rba
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpp4em1Rba mutation (0 available); any Dpp4 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• inflammatory infiltrates are seen in the lungs of mice infected with MERS-15 intranasally at day 3 post infection
• while mice support infection and replication of MERS-15, a mouse adapted MERS-CoV (MERS-0) via serial passage for 15 rounds through the lungs of heterozygous Dpp4em1Rba mice, heterozygotes show 100% survival with MERS-15 infection compared to homozygotes which show high mortality
• mice support efficient infection and replication of the human Middle East respiratory syndrome coronavirus (MERS-CoV) strain HCoV-EMC/2012, camel strain Dromedary/Al-Hasa-KFU-HKU13/2013, and recombinant virus derived from a molecular infectious clone (icMERS) in the lungs which is not seen in wild-type controls
• mice infected with MERS-15 intranasally, a mouse adapted MERS-CoV (MERS-0) via serial passage for 15 rounds through the lungs of heterozygous Dpp4em1Rba mice, show higher levels of MERS-15 replication in the lungs at 3 and 6 days post infection, while MERS-0 is cleared from the lungs by 6 days post infection and no replication is seen in wild-type mice

mortality/aging
• while mice support infection and replication of MERS-15, a mouse adapted MERS-CoV (MERS-0) via serial passage for 15 rounds through the lungs of heterozygous Dpp4em1Rba mice, heterozygotes show 100% survival with MERS-15 infection compared to homozygotes which show high mortality

respiratory system
• severe hemorrhage in the lungs is seen in mice infected with MERS-15 intranasally at days 3 and 6 post infection
• mice infected with MERS-15 intranasally show intra-alveolar edema
• inflammatory infiltrates are seen in the lungs of mice infected with MERS-15 intranasally at day 3 post infection
• mice infected with MERS-15 intranasally show hyaline membrane formation at day 6 post infection
• mice infected with MERS-15 intranasally show increased enhanced pause (Penh), a measure reflecting airway obstruction/restriction due to debris in the airway, and increased midtidal expiratory flow (EF50), representing the flow rate at which 50% of tidal volume is expelled in a single breath, up to day 6 post infection indicating severe respiratory distress
• mice infected with MERS-15 intranasally show pathology associated with severe acute respiratory distress, including hyaline membrane formation, intra-alveolar edema, perivascular cuffing and severe inflammation at day 6 post infection

cardiovascular system
• severe hemorrhage in the lungs is seen in mice infected with MERS-15 intranasally at days 3 and 6 post infection

growth/size/body
• mice infected with MERS-15 intranasally show 20-25% weight loss by days 6 post infection compared to mice infected with MERS-0 or wild-type mice injected with MERS-15

homeostasis/metabolism
N
• blood glucose levels are normal
• mice infected with MERS-15 intranasally show intra-alveolar edema

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Middle East respiratory syndrome DOID:0080642 J:279834


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory