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Phenotypes Associated with This Genotype
Genotype
MGI:6388425
Allelic
Composition
Wdr62tm1.1Jfch/Wdr62tm1.1Jfch
Genetic
Background
involves: 129S1/SvImJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr62tm1.1Jfch mutation (0 available); any Wdr62 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• slight, but significant, increase in the median length of primary cilia in neural progenitor cells
• slight increase in cilium number in the cerebral cortex
• while MEFs show normal cilium assembly, MEFs show an increase in cilium length at 24 hours after serum re-addition and an increase in the percentage of ciliated MEFs after serum re-addition, indicating a delay in cilium disassembly
• MEFs show delayed cell cycle re-entry after growth stimulation
• neural progenitor cells exhibit an increase in cell cycle length and a decrease in S-phase length indicating disrupted cell cycle progression
• increase in apoptotic cells in the cortex
• neural progenitor cells show precocious cell cycle exit indicating premature differentiation
• MEFs grown in culture stimulated for cell cycle re-entry show a decrease in the percentage of EdU+ cells

nervous system
• increase in apoptotic cells in the cortex
• neural progenitor cells show precocious cell cycle exit indicating premature differentiation
• smaller brain size is seen at E18.5 and P30 with mice showing mild microcephaly
• decrease in brain weight is detected at E18.5
• decrease in neocortical radial thickness
• numbers of Pax6+ apical neural progenitor cells and Tbr2+ intermediate progenitor cells are decreased at E16.5 and E18.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory