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Phenotypes Associated with This Genotype
Genotype
MGI:6382782
Allelic
Composition
Kctd9em1Beij/Kctd9em1Beij
Genetic
Background
BALB/c-Kctd9em1Beij
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd9em1Beij mutation (0 available); any Kctd9 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice infected with MHV-3 compared with infected wild-type mice

immune system
• reduced refined NK progenitor cells, but not pre-NKPs in the bone marrow
• a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells with increased CD11b-CD27+ NK cells indicating reduced maturation
• in the liver
• against Yac-1 in vitro
• increased CD11b-CD27+ NK cells with a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells indicating reduced maturation
• reduced NK cell activation in mice infected with MHV-3 compared with infected wild-type mice
• increased proliferation of CD11b- or CD11b+ NK cells in the bone marrow and spleen
• increased proliferation in response to IL15 stimulation
• NK cells stimulated with IL12 and IL18 exhibit decreased effector function compared with wild-type cells
• mice infected with MHV-3 exhibit alleviated liver damage (reduced alanine and asparagine amino transferase), reduced NK cell activation and improved survival compared with wild-type mice
• in mice infected with MHV-3 compared with infected wild-type mice

homeostasis/metabolism
• in mice infected with MHV-3 compared with infected wild-type mice
• in mice infected with MHV-3 compared with infected wild-type mice

hematopoietic system
• reduced refined NK progenitor cells, but not pre-NKPs in the bone marrow
• a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells with increased CD11b-CD27+ NK cells indicating reduced maturation
• in the liver
• against Yac-1 in vitro
• increased CD11b-CD27+ NK cells with a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells indicating reduced maturation
• reduced NK cell activation in mice infected with MHV-3 compared with infected wild-type mice
• increased proliferation of CD11b- or CD11b+ NK cells in the bone marrow and spleen
• increased proliferation in response to IL15 stimulation
• NK cells stimulated with IL12 and IL18 exhibit decreased effector function compared with wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory