Phenotypes Associated with This Genotype

Genotype
MGI:6382782

• Allelic Composition: Kctd9^em1Beij/Kctd9^em1Beij
• Genetic Background: BALB/c-Kctd9^em1Beij

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:281803 )

• in mice infected with MHV-3 compared with infected wild-type mice

immune system

abnormal NK cell differentiation ( J:281803 )

• reduced refined NK progenitor cells, but not pre-NKPs in the bone marrow

decreased mature NK cell number ( J:281803 )

• a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells with increased CD11b-CD27+ NK cells indicating reduced maturation

increased NK cell number ( J:281803 )

• in the liver

increased immature NK cell number ( J:281803 )

• against Yac-1 in vitro

abnormal immature NK cell morphology ( J:281803 )

• increased CD11b-CD27+ NK cells with a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells indicating reduced maturation

abnormal NK cell physiology ( J:281803 )

• reduced NK cell activation in mice infected with MHV-3 compared with infected wild-type mice

• increased proliferation of CD11b- or CD11b+ NK cells in the bone marrow and spleen

• increased proliferation in response to IL15 stimulation

• NK cells stimulated with IL12 and IL18 exhibit decreased effector function compared with wild-type cells

impaired natural killer cell mediated cytotoxicity ( J:281803 )

• against Yac-1 in vitro

decreased susceptibility to Coronaviridae infection ( J:281803 )

• mice infected with MHV-3 exhibit alleviated liver damage (reduced alanine and asparagine amino transferase), reduced NK cell activation and improved survival compared with wild-type mice

decreased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:281803 )

• in mice infected with MHV-3 compared with infected wild-type mice

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:281803 )

• in mice infected with MHV-3 compared with infected wild-type mice

decreased circulating aspartate transaminase level ( J:281803 )

• in mice infected with MHV-3 compared with infected wild-type mice

hematopoietic system

abnormal NK cell differentiation ( J:281803 )

• reduced refined NK progenitor cells, but not pre-NKPs in the bone marrow

decreased mature NK cell number ( J:281803 )

• a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells with increased CD11b-CD27+ NK cells indicating reduced maturation

increased NK cell number ( J:281803 )

• in the liver

increased immature NK cell number ( J:281803 )

• against Yac-1 in vitro

abnormal immature NK cell morphology ( J:281803 )

• increased CD11b-CD27+ NK cells with a reduction in CD11b+CD27- and/or CD11b+CD27+ NK cells indicating reduced maturation

abnormal NK cell physiology ( J:281803 )

• reduced NK cell activation in mice infected with MHV-3 compared with infected wild-type mice

• increased proliferation of CD11b- or CD11b+ NK cells in the bone marrow and spleen

• increased proliferation in response to IL15 stimulation

• NK cells stimulated with IL12 and IL18 exhibit decreased effector function compared with wild-type cells

impaired natural killer cell mediated cytotoxicity ( J:281803 )

• against Yac-1 in vitro