Phenotypes Associated with This Genotype

Genotype
MGI:6357214

• Allelic Composition: Mir199a-2^tm1Kinn/Mir199a-2^tm1Kinn
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:256665 )

• mice begin to die at around 6 weeks of age

growth/size/body

decreased body size ( J:256665 )

decreased body weight ( J:256665 )

behavior/neurological

abnormal pilomotor reflex ( J:256665 )

• mice develop pilar erection after 3 weeks of age

tremors ( J:256665 )

• mice develop body trembling after 3 weeks of age

abnormal gait ( J:256665 )

• mice develop a stiff, uncoordinated gait after 3 weeks of age

decreased locomotor activity ( J:256665 )

• mice show hypoactivity after 3 weeks of age

nervous system

decreased brain size ( J:256665 )

small hippocampus ( J:256665 )

abnormal neuron morphology ( J:256665 )

• cortical neurons exhibit a smaller cell body and nucleus and are more densely packed

abnormal hippocampus neuron morphology ( J:256665 )

• hippocampal neurons exhibit a smaller cell body and nucleus are more densely packed

respiratory system

abnormal breathing pattern ( J:256665 )

• mice develop irregular breathing after 3 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:256665