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Phenotypes Associated with This Genotype
Genotype
MGI:6343406
Allelic
Composition
Gas2l2tm1c(KOMP)Wtsi/Gas2l2tm1c(KOMP)Wtsi
Foxj1tm1.1(cre/ERT2/GFP)Htg/Foxj1+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1.1(cre/ERT2/GFP)Htg mutation (1 available); any Foxj1 mutation (5 available)
Gas2l2tm1c(KOMP)Wtsi mutation (0 available); any Gas2l2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity
• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment
• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities

growth/size/body
• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity
• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment
• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities

nervous system
• about 3% of tamoxifen-treated mice exhibit hydrocephalus

respiratory system
• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity
• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment
• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities
• mucociliary clearance is impaired in tamoxifen-treated mice, with impairment of clearance correlated with changes in nasal air space and presence of mucus in the nose
• effective speed of mucociliary clearance is slower and the directionality of the flow is affected in tamoxifen-treated mice with increased nasal air space and mucus accumulation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary ciliary dyskinesia DOID:9562 OMIM:PS244400
J:277289


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory