Phenotypes Associated with This Genotype

Genotype
MGI:6305814

• Allelic Composition: H2^u/H2^u; Rag1^tm1Mom/Rag1^tm1Mom; Tg(Tcra19,Tcrb19)#Stl/0
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to autoimmune disorder ( J:19795 )

• 100% of mice develop spontaneous autoimmune encephalomyelitis within 12 months

• onset and rate of progression of disease varies, with an average age of onset of 13 weeks

• cerebellum and spinal cord exhibit patchy lesions with mononuclear cell infiltrates

• activated myelin basic protein (MBP)-specific T cells are found in the brain but not in the peripheral lymphoid tissues

behavior/neurological

limb paralysis ( J:19795 )

• weakness or paralysis of the hind legs is seen first and then extends to the front legs

• once hind legs are completely paralyzed, the disease progresses very rapidly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:19795