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Phenotypes Associated with This Genotype
Genotype
MGI:6305814
Allelic
Composition
H2u/H2u
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2u mutation (6 available); any H2 mutation (274 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (92 available)
Tg(Tcra19,Tcrb19)#Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 100% of mice develop spontaneous autoimmune encephalomyelitis within 12 months
• onset and rate of progression of disease varies, with an average age of onset of 13 weeks
• cerebellum and spinal cord exhibit patchy lesions with mononuclear cell infiltrates
• activated myelin basic protein (MBP)-specific T cells are found in the brain but not in the peripheral lymphoid tissues

behavior/neurological
• weakness or paralysis of the hind legs is seen first and then extends to the front legs
• once hind legs are completely paralyzed, the disease progresses very rapidly

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
J:19795


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory