Phenotypes Associated with This Genotype

Genotype
MGI:6296609

• Allelic Composition: Cdh1^tm1Jjon/Cdh1^tm1Jjon; Trp53^tm1Brn/Trp53⁺; Tg(Wap-cre)51Nki/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:171765 )

♀ • mice exhibit invasive mammary tumors which show phenotypic similarity to invasive lobular carcinoma

♀ • females also develop solid carcinoma/carcinosarcoma that predominantly exhibit a mixed epithelial and mesenchymal or spindle-shaped cell morphology and show both expansive and invasive growth patterns

hypolactation ( J:171765 )

♀ • pups show reduced survival rates due to inhibition or absence of lactation

integument

increased mammary gland tumor incidence ( J:171765 )

♀ • mice exhibit invasive mammary tumors which show phenotypic similarity to invasive lobular carcinoma

♀ • females also develop solid carcinoma/carcinosarcoma that predominantly exhibit a mixed epithelial and mesenchymal or spindle-shaped cell morphology and show both expansive and invasive growth patterns

hypolactation ( J:171765 )

♀ • pups show reduced survival rates due to inhibition or absence of lactation

neoplasm

increased mammary gland tumor incidence ( J:171765 )

♀ • mice exhibit invasive mammary tumors which show phenotypic similarity to invasive lobular carcinoma

♀ • females also develop solid carcinoma/carcinosarcoma that predominantly exhibit a mixed epithelial and mesenchymal or spindle-shaped cell morphology and show both expansive and invasive growth patterns

increased metastatic potential ( J:171765 )

♀ • 70% of females that present mammary tumors of about 1 cm show extensive local invasion and metastases to draining and distant lymph nodes