About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6295359
Allelic
Composition
Gnao1tm2Rneu/Gnao1+
Genetic
Background
B6.129S1-Gnao1tm2Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation (0 available); any Gnao1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• both males and females show reduced activity in the first 10 min of the open field arena indicating decreased activity in a novel environment
• females exhibit a reduced retention time on the accelerating rotarod, while males are unaffected
• however, mice do not show a difference in learning rate on the rotarod
• females, but not males, show reduced forepaw grip strength
• mice exhibit reduced activity in the open field arena, with both males and females showing reduced activity in the first 10 minutes (novel environment), and females, but not males, showing reduced activity in the next 10-30 min designated as sustained activity
• both males and females show reduced total activity
• females exhibit abnormal gait with reduced stride length and increased paw angle variability while males only show increased paw angle variability
• females show reduced stride length

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 17 DOID:0080450 OMIM:615473
J:271137


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/23/2021
MGI 6.16
The Jackson Laboratory