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Phenotypes Associated with This Genotype
Genotype
MGI:6295357
Allelic
Composition
Gnao1em1Rneu/Gnao1+
Genetic
Background
involves: C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1em1Rneu mutation (0 available); any Gnao1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 2 of 33 mice die spontaneously around 5-7 weeks of age

behavior/neurological
• a significant number of mice of both sexes fail to run when the belt speed exceeds 22 cm/s
• males exhibit a reduced retention time on the accelerating rotarod, while females are unaffected
• however, mice do not show a difference in learning rate on the rotarod and mice exhibit normal performance in the open field arena
• both males and females exhibit a decrease in forepaw grip strength
• males exhibit abnormal gait, with males, but not females, showing increased paw angle variability and reduced stride length
• seen in males but not females
• males show increased sensitivity to pentylenetetrazole (PTZ) kindling
• however, no spontaneous seizures are seen

nervous system
• males show increased sensitivity to pentylenetetrazole (PTZ) kindling
• however, no spontaneous seizures are seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 17 DOID:0080450 OMIM:615473
J:271137


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory