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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
• life expectancy is reduced

• lower mean body weight, with this difference increasing with age

• in the Y-maze test of short-term spatial memory, spontaneous alternation behavior is impaired in 5 month old mice
• in the novel object recognition test, 5 month old mutant mice show less exploratory preference for the novel object than for the previously presented object
• in the novel object recognition test, 5 month old mutant mice exhibit similar exploratory activity around both trial objects as wild-type mice although mutants tend to explore objects for longer period than wild-type mice
• mice exhibit motor deficits at 8.5 months of age but not at 5 months
• mice cross their hindlimbs when lifted by the tail

nervous system
• mice exhibit age dependent intracellular accumulation and insolubilzation of tau by 9 months of age, indicating age-dependent tauopathy-like tau accumulation
• 5 month old mice exhibit impaired axonal transport in the septohippocampal pathway

• dynamics of tau-associated microtubules are accelerated in both the cortex and hippocampus but not the cerebellum in 4 and 7 month old mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
tauopathy DOID:680 J:213361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory